Herbal Andrographolide processed an anti cognitive impairment effect in the prevention of the early stage of dementia, a study conducted by a renowned institute suggested.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
According to the joint study lead by the Pontificia Universidad Catolica de Chile, oral administrated natural product (Andrographolide, ANDRO) isolated from Andrographis paniculata in species Octodon degus (degu) exhibited the recovery of spatial memory and learning performance, through regulated phosphorylated tau protein and amyloid-beta aggregate maturation in cell survival in inducing Alzheimer's disease.
Dr., the lead author in the joint study said, "(Andrographolide, ANDRO) inhibited) neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD"
Additionally, Andrographolide also displayed the inhibitory activity against forming of amyloid-beta (Aβ)42 through suppression of NF-κB, a protein in regulated cell survival and function of microglia in activated response to brain damage and immunological stimuli together with the reduction in the production of inflammatory cytokines.
In an animal study, mice treated with Andrographolide increased neural progenitor cell proliferation and the number of immature neurons in the hippocampus compared to age-matched control mice.
Moreover, ANDRO stimulated neurogenesis increasing the number of newborn dentate granule neurons in various parts of the brain.
The study also found that the efficacy of reduced symptoms and protect against the early onset of AD is the result of the stimulation of neurogenesis in the hippocampus.
Taking together, Andrographis paniculata is sure consisted of a therapeutic potential to protect the development of Alzheimer's disease through various mechanisms, however, intake of large amounts daily should be taken with care.
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(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.(PubMed)
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