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Sunday, May 15, 2016

The Smoothie for Prevention and Treatment of Cardiorenal syndrome (The Co-existed Cardiovascular disease and Kidney disease)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Cardiorenal syndrome is a term of interrelated of kidney and cardiovascular. As one disease of 
one organ can induce dysfunction of the other. The coexisting CVD and kidney disease or 'cardiorenal syndrome (CRS)' have a synergistic adverse clinical outcomes.

The smoothie for prevention and treatment of  Kidney disease induced Cardiovascular disease in Cardiorenal syndrome
Yield: 2 servings (about 8 ounces each)

1/2 cup olive
1 cup cooked sweet potato
1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding of a natural source for treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome

Chronic Kidney Diseases(CKD) in in Autosomal recessive polycystic kidney disease is a progressive loss of kidney function over period longer than 3 months through different stages, deepening to the GFR (Glomerular Filtration Rate). According to the Tri-Service General Hospital, Excessive oxidative stress increased oxidative nucleicacid damage and exagerated the development of complication of Chronic Kidney Diseases(1).

The Anti-Odxidant Therapy in Chronic Renal Insufficiency (ATIC) study suggested, combination of pravastatin, vitamin E, and homocysteine treatment in 18 months together with hypertension controlled  effectively attenuated expression of Chronic Kidney Diseases(CKD) through reduced oxidative stress against renal function(2).Vitamin E-coated membranes (VECMs) consist of a multilayer membrane with liposoluble vitamin E, used in dialysis significantly improved Hb levels and lower rHuEpo requirements in chronic HD patients(3).Dr. Rashid Khan M and colleagues insisted, vitamin E significantly reduced dyslipidemia and inhibited the development of CRD caused by atherogenic factors after six weeks. particular in hypolipidemic and nephroprotective activity against free radical-related diseases(4).

N-3 fatty acids found abundantly in olive may also contribute to the potential benefits of dietary fat
modification in CKD patients, according to the Karolinska Institutet(5).
Dr. Lee SM and Dr. An WS., professors at the Seoul National University Hospital, insisted, intake of Omega 3 fatty acid exhibited cardioprotective effects in chronic kidney disease, the main cause of death, through attenuated inflammation, dyslipidemia, malnutrition, atherosclerosis, and vascular calcification(6).
Dr. Friedman AN said, " Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA), which are obtained primarily from dietary sources such as coldwater fish, have diverse and potent mediating effects on the immune, inflammatory, and metabolic pathways, signal transduction, and cell membrane physiology" and "In the meantime, the current American Heart Association n-3 PUFA intake guidelines can be applied to CKD patients"(7).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry, may also benefit in attenuated complications and treatment of Chronic Kidney Diseases(CKD), through its inflammation and oxidative stress modulation (8).
According to the joint study led by the The Catholic University of Korea, Bucheon, resveratrol expressed renoprotective effects by activating NRF2 signaling against against oxidative or electrophilic stress(9).Furthermore by suppressing the pro inflammatory cytokines, consumption of white wine and olive oil, significantly reduced plasma markers of chronic inflammation in CKD patients(10).

The effectiveness of Cooked Sweet Potato, Olive and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndromewith little or no adverse effects.

People who are at high risk of Kidney disease (induced Cardiovascular disease) in Cardiorenal syndrome should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.


The smoothie for prevention and Treatment of Cardiovascular disease induced Kidney disease in Cardiorenal syndrome

Yield: 2 serving (about 8 ounce each)
1 cup Blueberry
1/4 cup avocado
1/4 cup raw flax seed
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of heart disease with adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.
Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease.
Scientist community may have found the smoothie(combined ingredients of green tea) with potential and therapeutic value for reduced risk and treatment of heart disease without adverse effects.


Blueberry is a flower plant, belonging to the family Eriaceae and native to Northern America, cultivated all over the world in suitable climate for its health benefits and commercial profits. Recent study suggested that blueberry may have a potential to become a pharmaceutical ingredient for treatment of heart disease(1) due to its phytochemical procyanidin composition and total anthocyanin contents(10).

According to the National Institutes of Health, blueberry enriched diet (BD) has exhibited protective effects on myocardium from induced ischemic damage and demonstrated the potential to attenuate the development of post MI chronic heart failure(11).

Furthermore, Dr. Ahmet I and the research team at the same institution said" a blueberry-enriched diet has positive effects on the course of CHF and thus warrants consideration for clinical evaluation"(12).

Blueberry anthocyanins-enriched extracts (BAE) inprove heart function by attenuated mean arterial blood pressure, heart rate and activities of heart enzymes, improved cardiac dysfunction, left ventricular hypertrophy and fibrosis, through decreased inflammatory cytokines expression, ameliorated oxidative stress,...(13) on cyclophosphamide (CTX)-induced cardiac injury.

Avocados are a commercially valuable fruit and are cultivated in tropical climates throughout the world, it is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae.

According to the University of KwaZulu-Natal, intake of acovado leaf extract (PAE) used as a natural supplementary remedy showed to inhibit hypertension and certain cases of cardiac dysfunctions in some rural Africa communities(14).
In animal model, combination of aqueous extract containing leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) exhibited antihypertensive activity against ethanol and sucrose induced hypertension in rats by the improvement of biochemical and oxidative status(15).
Furthermore, Dr. Rodriguez-Sanchez D and the research team at the Tecnológico de Monterrey, avocado due to its acetogenin compounds, inhibited platelet aggregation with a potential preventive effect on thrombus formation, such as those that occur in ischaemic disease(16).

Flax seed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed. n-3 polyunsaturated fatty acids (PUFAs), the main ingredient found in flax seed exhibit cardio protective effects through defending cardiomyocytes against the cell signalling protein TNF in pro-apoptotic action and preventing cardiac degenerative diseases(17).
According to the University of Manitoba, flax seed also retarded the progression of atherosclerotic plaques resulting in a significant ≈40% reduction in plaque formation(18).
In New Zealand White rabbits study, flaxseed supplementation effectively limit cholesterol-induced atherogenesis and abnormalities in endothelial-dependent vasorelaxation(19).

People who are at increased of Cardiovascular disease due to family history, obesity.....should drink at least one serving daily and people with Cardiovascular disease should drink no more than 4 serving a day, depending to digestive toleration.
Change of  life style and diet pattern are also recommended.


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References
(1) Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease by Sung CC1, Hsu YC, Chen CC, Lin YF, Wu CC.(PubMed)
(2) Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study by Nanayakkara PW1, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD.(PubMed)
(3) Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study by Cruz DN1, De Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C.(PubMed)
(4) Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats by Rashid Khan M1, Ahsan H, Siddiqui S, Siddiqui WA.(PubMed)
(5) Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond by Huang X1, Lindholm B, Stenvinkel P, Carrero JJ.(PubMed)
(6) Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. by Lee SM1, An WS.(PubMed)
(7) Omega-3 fatty acid supplementation in advanced kidney disease by Friedman AN1.(PubMed)
(8) Resveratrol: why is it a promising therapy for chronic kidney disease patients?by Saldanha JF1, Leal Vde O2, Stenvinkel P3, Carraro-Eduardo JC4, Mafra D1.(PubMed)
(9) Effect of redox modulating NRF2 activators on chronic kidney disease.by Choi BH1, Kang KS2, Kwak MK3.(PubMed)
References
(10) Influence of extrusion processing on procyanidin composition and total anthocyanin contents of blueberrypomace by Khanal RC1, Howard LR, Brownmiller CR, Prior RL.(PubMed)
(11) Blueberry-enriched diet protects rat heart from ischemic damage by Ahmet I1, Spangler E, Shukitt-Hale B, Juhaszova M, Sollott SJ, Joseph JA, Ingram DK, Talan M.(PubMed)
(12) Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats by Ahmet I1, Spangler E, Shukitt-Hale B, Joseph JA, Ingram DK, Talan M.(PubMed)
(13) Blueberry Anthocyanins-Enriched Extracts Attenuate Cyclophosphamide-Induced Cardiac Injury. by Liu Y1, Tan D2, Shi L1, Liu X1, Zhang Y1, Tong C1, Song D2, Hou M1.(PubMed)
(14) Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals by Ojewole JA1, Kamadyaapa DR, Gondwe MM, Moodley K, Musabayane CT.(PubMed)
(15) Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model. by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P.(PubMed)
(16) Isolation and chemical identification of lipid derivatives from avocado (Persea americana) pulp with antiplatelet and antithrombotic activities by Rodriguez-Sanchez DG1, Flores-García M, Silva-Platas C, Rizzo S, Torre-Amione G, De la Peña-Diaz A, Hernández-Brenes C, García-Rivas G.(PubMed)
(17) A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression by Carotenuto F1, Minieri M, Monego G, Fiaccavento R, Bertoni A, Sinigaglia F, Vecchini A, Carosella L, Di Nardo P.(PubMed)
(18) Effects of dietary flaxseed on atherosclerotic plaque regression by Francis AA1, Deniset JF, Austria JA, LaValleé RK, Maddaford GG, Hedley TE, Dibrov E, Pierce GN.(PubMed)
(19) Effects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits by Dupasquier CM1, Weber AM, Ander BP, Rampersad PP, Steigerwald S, Wigle JT, Mitchell RW, Kroeger EA, Gilchrist JS, Moghadasian MM, Lukas A, Pierce GN.(PubMed)

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