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Gou Sui Bu is also known as Drynaria Rhizome. The bitter and warm herb has been used in TCM as anti-inflammatory, anti-biotic, etc. and to treat painful and weak join and knees, diarrhea, tinnitus, toothache, etc., as it tonifies the Kidneys, moves Blood, stops bleeding, promotes tissue regeneration, etc., by enhancing the functions of liver and kidney channels.
2. Hydrolysis naringenin
1. Anti-osteoporosis effect
In the study to establish the rats plasma metabonomic profiles of control, model and treatment group, then to investigate the anti-osteoporosis effect of Rhizoma Drynariae (RD and its action mechanism, found that the anti-osteoporosis effect of RD has been reliably confirmed by the metabonomics method. The osteoporosis might be prevented by RD via intervening antioxidant-oxidation balance, tryptophane metabolism and phenylalanine metabolism in vivo in rats, according to “Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography-tandem mass spectrometry” by Liu X, Zhang S, Lu X, Zheng S, Li F, Xiong Z.(1).
2. Bone formation
In the investigation of the effects of traditional Korean medicine, Drynariae Rhizoma [Drynaria fortunei (kunze) J. Sm] extract (DR), on the osteoblastic proliferation and differentiation, found that DR dose-dependently increased DNA synthesis (significant at 50-150 microg/ml). DR increased alkaline phosphatase (ALP) activity and prolyl hydroxylase activity of MC3T3-E1 cells (50-150 microg/ml). Antiestrogen tamoxifen eleminated the stimulation of proliferation and ALP activity of MC3T3-E1, which were induced by DR. DR at concentrations ranged from 30-100 microg/ml inhibited prostaglandin E2 production in MC3T3-E1, according to “Stimulative effects of Drynariae Rhizoma extracts on the proliferation and differentiation of osteoblastic MC3T3-E1 cells” by Jeong JC, Lee JW, Yoon CH, Lee YC, Chung KH, Kim MG, Kim CH.(2).
3. Rheumatoid arthritis
In the study of eighteen patients with early active RA were randomized into the BZXD group and the methotrexate (MTX) group, nine in each group, they were treated with BZXD (contained 15 Chinese herbs, as Herba Hedyotis diffusae, Herba Sarcandrae glabrae, Radix Salviae miltiorrhizae, Caulis Trachelosperi, Rhizoma Drynariae, Semen Coicis, etc.) and MTX combined with nimesulide Tablets, found that The 2-DE protein profile of PBMCs from healthy persons and RA patients before and 3 months after treatment were obtained, and 23 differential protein spots were found, 14 from 18 differential protein spots were successfully identified, of which 8 proteins were up-regulated and 6 proteins were down-regulated in RA patients as compared with control. After 3-month treatment, 5 differentially expressed proteins showed more obvious in the BZXD group than in the MTX group. RT-PCR verified that the expression of ApoA-I in all the three groups was consistent with the outcomes of 2-DE, according to “[Effect of Bizhongxiao decoction on proteomics of peripheral blood mononuclear cells in patients with rheumatoid arthritis].[Article in Chinese]” by Jiang YQ, Liang QH, Xiong XG.(3).
4. Reflex sympathetic dystrophy (RSD)
In the observation of the clinical results of Chinese herbs promoting blood circulation and removing blood stasis on the treatment of reflex sympathetic dystrophy (RSD) with type of stagnation of vital energy and blood stasis, found that With the different treatment based on different syndrome and emphasis on the nourishment of bone and soft tissue, treated by Chinese medicine to promote blood circulation and remove blood stasis in stagnation of vital energy and blood stasis, RSD get a favorable result, according to “[Controlled clinical trials of therapeutic effects of Chinese herbs promoting blood circulation and removing blood stasis on the treatment of reflex sympathetic dystrophy with type of stagnation of vital energy and blood stasis].[Article in Chinese]” by Xu RS, Zong XH, Li XG.(4).
5. Serile dementia
In the assessment of the effect of Gu Sui Bu, a traditional Chinese medicine in treating serile dementia found that A decoction of 60g of Gu Sui Bu (Drynariae Rhizoma) was taken three times daily, along with 9g of Ba Wei Di Huang taken twice daily. After one month his symptoms
had slightly improved and urinary continence regained. The dosage of the herb was then
increased to 120g. After five months of treatment the patient was completely continent and
could converse normally although his limbs were still weak. Treatment was continued and
after two years his cognitive ability had improved further, the limbs had regained strength
and the blood pressure had normalised. This case was useful as it demonstrated that in severe
cases success depends upon a high dose of herbs, according to “Gu Sui Bu (Drynariae Rhizoma) – a useful herb for senile dementia” by Yang Dingyou(5)
1. Do not use the herb in case of Yin deficiency and without blood stasis.
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without consulting first with the related field specialist.
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