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Sunday, May 22, 2016

Most common Diseases of 50plus: The Obesity' Research and Studies - Obesity and Weight Loss Hormone Ghrelin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)

Ghrelin is a hormone produced by the stomach and pancreas with the function of stimulating hunger to protect against the fat loss as a result of thousand years in protecting the survival of human species. Its levels increase before meals and decrease after meals. As to its unique activity, many researchers have tried to find a way to block the stimulation of this hormone for weight loss.

In the study of (a) changes in ghrelin and peptide YY (PYY) concentrations during a weight reduction programme and (b) baseline ghrelin and PYY levels during aweight reduction programme with 15 normal-weight teenagers and 32 severely obese adolescents (BMI z score = 4.1), researchers found that obese teenagers had lower ghrelin and PYY concentrations than normal-weight adolescents (P < 0.05). Moreover, they showed significantly higher leptin, insulin levels and homeostasis model assessment (HOMA) (P < 0.0001).). During the lifestyle modification, there was a significant decrease in body weight among obese teenagers, associated with an increase in ghrelin (apparent from month 6; P < 0.05), a decrease in leptin (from month 3; P < 0.05) and a decrease in insulin and HOMA (from month 3; P < 0.0001), without any significant change in PYY.
Researchers concluded that In adolescents with severe obesity, a long-term combination of supervised aerobic exercises and a balanced diet led to weightreduction and increased ghrelin concentrations, without any change in PYY concentrations. Moreover, baseline PYY concentrations might be considered as predictors of weight loss.(1).

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References
(1) "Ghrelin and PYY levels in adolescents with severe obesity: effects of weight loss induced by long-term exercise training and modified food habits." by Gueugnon C, Mougin F, Nguyen NU,Bouhaddi M, Nicolet-Guénat M, Dumoulin G. posted in PubMed

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