Saturday, June 25, 2016

Most Common Diseases of 50 Plus - Upper gastrointestinal disorders: Gastro-esophageal reflux disease (GERD) - Treatments In Conventional medicine Perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Upper gastrointestinal (GI) diseases

 The prevalence of upper gastrointestinal (GI) diseases is increasing in subjects aged 65 years and over. Pathophysiological changes in esophageal functions that occur with aging may, at least in part, be responsible for the high prevalence of
1. Gastro-esophageal reflux disease (GERD) in old age.

2. The incidence of gastric and duodenal ulcers and their bleeding complications is increasing in old-aged populations worldwide.

3. H. pylori infection in elderly patients with H. pylori-associated peptic ulcer disease and severe chronic gastritis.

4. Almost 40% of GU and 25% of DU in the elderly patients are associated with the use of NSAID(1) and/or aspirin(2).(a)

        Gastro-esophageal reflux disease (GERD)



Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.” by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus.

                              The Treatments

In Herbal Medicine
1. Deglycyrrhizinated licorice
Deglycyrrhizinated licorice has been used by people with gastric and peptic ulcers for nearly a hundred years. in a study of “Secretin as a potential mediator of antiulcer actions of mucosal protective agents.” by Takeuchi T, Shiratori K, Watanabe S, Chang JH, Moriyoshi Y, Shimizu K., posted in US National Library of Medicine National Institutes of Health, researcher found that the three antiulcer agents FM 100, plaunotol, and teprenon have been shown to increase the content of endogenous prostaglandins in the gastric mucosa, endogenous secretin released by these agents may play a significant role in their mucosal protective action. It is concluded that the antiulcer effect of these drugs could in part be attributable to their unique ability to release endogenous secretin, and that secretin is a potential mediator of the antiulcer actions of mucosal protective agents.

2. Aloe Vera
According to the article of “Effect Of Orally Consumed Aloe Vera Juice On Gastrointestinal Function In Normal Humans, excerpts By Jeffrey Bland, Ph.D. (Linus Pauling Institute of Science & Medicine) involved ten healthy subjects – five men (median age: 42; standard deviation: 14 years), and five women (median age: 32; standard deviation: 5 years) – engaged in a semicontrolled Aloe vera juice oral supplementation study protocol., researchers found that The function of Aloe vera juice in promoting, proper gastrointestinal function, based upon the
information from this preliminary study, may be to regulate gastrointestinal pH while improving
gastrointestinal motility, increasing stool specific gravity, and reducing populations of certain fecal micro-organisms, including yeast.

3. Mastic gum
According to the article of Strategies to Protect Against Potential Bone-Destroying Effects”By Chris D. Meletis, ND, the aithor wrote that While much of the research on mastic gum revolves around its ability to support the health of patients with ulcers and its ability to inhibit the bacteria H. pylori, clinically it has been equally useful in patients with GERD and acid reflux.

4. Ginger
Ginger has been used for thousands of years to enhance the function of digestive system and treat stomach distress including nausea, vomiting, diarrhea and in digestion, acid reflux, motion sickness, dyspepsia, etc. due to its due to its anti-inflammatory, antimicrobial and analgesic properties. According to the study of ” Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori.” by Mahady GB, Pendland SL, Yun GS, Lu ZZ, Stoia A., researchers found that The methanol extract of ginger rhizome inhibited the growth of all 19 strains in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml. One fraction of the crude extract, containing the gingerols, was active and inhibited the growth of all HP strains with an MIC range of 0.78 to 12.5 micrograms/ml and with significant activity against the CagA+ strains.


5. Peppermint
According to the study of A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.).” by McKay DL, Blumberg JB. posted in , researchers wrote that In vitro, peppermint has significant antimicrobial and antiviral activities, strong antioxidant and antitumor actions, and some antiallergenic potential. Animal model studies demonstrate a relaxation effect on gastrointestinal (GI) tissue, analgesic and anesthetic effects in the central and peripheral nervous system… However, human studies of peppermint leaf are limited and clinical trials of peppermint tea are absent. Adverse reactions to peppermint tea have not been reported, although caution has been urged for peppermint oil therapy in patients with GI reflux, hiatal hernia or kidney stones.

6. Etc.
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