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Polycystic Ovarian Syndrome
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
In Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.
Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).
The Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).
Life style Modification
1. Say goodby to Western lifestyle
Western lifestyle characterized by low levels of physical activity, and by an energy-dense diet rich in total and saturated fat and refined carbohydrates(1289) may consist a positive association between risk of breast cancer and subclinical forms of the polycystic ovary syndrome (PCOS)(1289) such as more severe phenotype with regard to insulin insensitivity, increased numbers of antral follicles at midcycle, and decreased circulating luteal phase progesterone levels(1290).
2. Avoid all refined sugars (white and brown sugars, fructose, sucrose, corn syrup) and simple sugars (maple syrup, honey)
Increased consumption of refined dietary sugars not only showed to contribute to a central factor in the rapidly rising rates of obesity(1293) and type 2 diabetes(1291)(1294) but also promoted risk of metabolic syndrome(1291)(1295) such as glucose intolerance(1292) and its complication(1295).
According to study by Dr. Kozlovsky AS and research team, diets high in simple sugars not only stimulates Cr losses and may lead to marginal Cr deficiency associated with impaired glucose and lipid metabolism(1296).
3. Say no refined carbohydrate (white bread, pasta, potatoes, white rice, most breakfast cereals, rice cakes, popcorn, or any starchy, low fiber food) (See dietary supplement 2 for more information)
[2. Women with PCOS should completely avoid refined carbohydrates as it showed to elevate the risk of type 2 diabetes(1254) induced collection of metabolic defects including peripheral insulin resistance(1255), elevated hepatic glucose output, and impaired pancreatic insulin secretion(1254), immune-mediated diseases(1256), such as reduced control of infection, increased rates of cancer, and increased risk for allergic and auto-inflammatory disease(1256) and inflammation(1255)].
4. Avoid artificial sweeteners
Artificial sweeteners has shown to induce glucose intolerance by altering the gut microbiome(1297)(1298) associated susceptibility to metabolic disease(1297)(1298).
5. Avoid large size in regular meals. Opt for smaller and more regular meals to moderate glucose load and minimize insulin resistance(see Dietary supplement 3. Keep blood sugar stable by eating regularly with small meal for more information)
[3. Keep blood sugar stable by eating regularly with small meal(1258), including good fat, such as monounsaturated and polyunsaturated fatty acids(1259) and protein(1261). According to Diabetes Center, Eulji Hospital, in the differentiation of a meal plan using rice bowls of varying sizes, showed that small rice bowl-based meal plan was effective at reducing dietary energy intake (EI), body weight (BW), and blood glucose levels in comparison to regular rice bowl-based meal plan(1257).
Indeed, high monounsaturated fat hypocaloric diet) or high polyunsaturated fat hypocaloric diet has shown to mprove total cholesterol, LDL cholesterol, triglyceride, glucose, insulin and homeostasis model assessment for insulin resistance(HOMA-R) levels(1260)].
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(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1247b) Polycystic Ovary Syndrome - a TCM Perspective by Donna Dupre, L.Ac.
(1248) Spleen-yang-deficiency patients with polycystic ovary syndrome have higher levels of visfatin by Fu H, Qiu Y, Xia M, Wei F, He H, Yang L.(PubMed)
(1249) PCOS – A Chinese Medicine Diet and Lifestyle Approach by Angela Warburton
(1250) An isocaloric low glycemic index diet improves insulin sensitivity in women with polycystic ovary syndrome by Barr S, Reeves S, Sharp K, Jeanes YM.(PubMed)
(1251) Habitual dietary intake, eating pattern and physical activity of women with polycystic ovary syndrome by Barr S1, Hart K, Reeves S, Sharp K, Jeanes YM.(PubMed)
(1252) Evaluating compliance to a low glycaemic index (GI) diet in women with polycystic ovary syndrome (PCOS) by Egan N1, Read A, Riley P, Atiomo W.(PubMed)
(1253) Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines by Moran LJ1, Ko H, Misso M, Marsh K, Noakes M, Talbot M, Frearson M, Thondan M, Stepto N, Teede HJ.(PubMed)
(1254) Dietary substitutions for refined carbohydrate that show promise for reducing risk of type 2 diabetes in men and women. Maki KC1, Phillips AK2.(PubMed)
(1255) improved Excessive refined carbohydrates and scarce micronutrients intakes increase inflammatory mediators and insulin resistance in prepubertal and pubertal obese children independently of obesity by López-Alarcón M1, Perichart-Perera O2, Flores-Huerta S3, Inda-Icaza P4, Rodríguez-Cruz M1, Armenta-Álvarez A1, Bram-Falcón MT1, Mayorga-Ochoa M1.(PubMed)
(1256) the risk of Fast food fever: reviewing the impacts of the Western diet on immunity. Myles IA1.(PubMed)
(1257) The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus. Ahn HJ1, Han KA, Kwon HR, Min KW.(PubMed)
(1258) Effect of meal frequency on blood glucose, insulin, and free fatty acids in NIDDM subjects. Bertelsen J, Christiansen C, Thomsen C, Poulsen PL, Vestergaard S, Steinov A, Rasmussen LH, Rasmussen O, Hermansen K.(PubMed)
(1259) Serum hyperglycemia might be not related to fat composition of diet and vegetable composition of diet might improve sugar control in taiwanese diabetic subjects by Hou YC1, Chang YL1, Kuo SC1, Chiang CF1, Chiang CY1, Lin YF1, Weng PC1, Hu FC1, Wu JH1, Lai CH2.(PubMed)
(1260) Genetic variation in the beta 3-adrenoreceptor gene (Trp64Arg polymorphism) and its influence on anthropometric parameters and insulin resistance under a high monounsaturated versus a high polyunsaturated fat hypocaloric diet by de Luis DA1, Aller R, Izaola O, Conde R, Eiros Bouza JM.(PubMed)
(1261) Protein: metabolism and effect on blood glucose levels by Franz MJ1.(PubMed)
(1262) DASH diet, insulin resistance, and serum hs-CRP in polycystic ovary syndrome: a randomized controlled clinical trial by Asemi Z1, Esmaillzadeh A2.(PubMed)
(1263) Diets containing traditional and novel green leafy vegetables improve liverfatty acid profiles of spontaneously hypertensive rats by Johnson M, Pace RD, Dawkins NL, Willian KR1.(PubMed)
(1264) Liver protein profiles in insulin receptor-knockout mice reveal novel molecules involved in the diabetes pathophysiology by Capuani B1, Della-Morte D2, Donadel G1, Caratelli S1, Bova L1, Pastore D1, De Canio M3, D'Aguanno S4, Coppola A1, Pacifici F1, Arriga R1, Bellia A5, Ferrelli F1, Tesauro M5, Federici M5, Neri A6, Bernardini S7, Sbraccia P5, Di Daniele N5, Sconocchia G8, Orlandi A9, Urbani A3, Lauro D10.(PubMed)
(1265) Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21 by Kim H1, Mendez R, Zheng Z, Chang L, Cai J, Zhang R, Zhang K.(PubMed)
(1266) Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice by Chang HP1, Wang ML, Chan MH, Chiu YS, Chen YH.(PubMed)
(1267) Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3'-diindolylmethane in high-fat diet-induced C57BL/6J mice by Poornima J1, Mirunalini S.(PubMed)
(1268) Indole-3 carbinol(Natural science comprehensive database)
(1269) The effects of legumes on metabolic features, insulin resistance and hepatic function tests in women with central obesity: a randomized controlled trial by Alizadeh M1, Gharaaghaji R2, Gargari BP3.(PubMed)
(1270) Dietary Patterns Are Associated with Metabolic Risk Factors in South Asians Living in the United States by Gadgil MD1, Anderson CA2, Kandula NR3, Kanaya AM4.(PubMed)
(1271) Chi Xiao Tou(Complementary and Alternative Healing University)
(1272) Pig feeds rich in rapeseed products and organic selenium increased omega-3 fatty acids and selenium in pork meat and backfat by Gjerlaug-Enger E1, Haug A2, Gaarder M3, Ljøkjel K4, Stenseth RS5, Sigfridson K6, Egelandsdal B7, Saarem K3, Berg P3.(PubMed)
(1273) A review of fatty acid profiles and antioxidant content in grass-fed andgrain-fed beef by Daley CA1, Abbott A, Doyle PS, Nader GA, Larson S.(PubMed)
(1274) Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human health by Ponnampalam EN1, Mann NJ, Sinclair AJ.(PubMed)
(1275) Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice by Heyman L1, Axling U1, Blanco N2, Sterner O2, Holm C1, Berger K1.(PubMed)
(1276) Polyphenol-rich bilberry ameliorates total cholesterol and LDL-cholesterol when implemented in the diet of Zucker diabetic fatty rats. Brader L1, Overgaard A1, Christensen LP2, Jeppesen PB1, Hermansen K1.(PubMed)
(1277) Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice by Takikawa M1, Inoue S, Horio F, Tsuda T.(PubMed)
(1278) Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome by Puupponen-Pimiä R1, Seppänen-Laakso T, Kankainen M, Maukonen J, Törrönen R, Kolehmainen M, Leppänen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tómas-Barberán FA, Espín JC, Oksman-Caldentey KM.(PubMed)
(1279) Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women by Lehtonen HM1, Suomela JP, Tahvonen R, Yang B, Venojärvi M, Viikari J, Kallio H.(PubMed)
(1280) The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: a systematic review and meta-analysis by Yin RV1, Lee NC1, Hirpara H1, Phung OJ1.(PubMed)
(1281) Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients by Fuangchan A1, Sonthisombat P, Seubnukarn T, Chanouan R, Chotchaisuwat P, Sirigulsatien V, Ingkaninan K, Plianbangchang P, Haines ST.(PubMed)
(1282) Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome by Alam MA1, Uddin R2, Subhan N3, Rahman MM1, Jain P1, Reza HM1.(PubMed)
(1283) Protective effect of Momordica charantia fruit extract on hyperglycaemia-induced cardiac fibrosis by Abas R1, Othman F2, Thent ZC2.(PubMed)(1284) Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study by Rao A1, Steels E, Beccaria G, Inder WJ, Vitetta L., (PubMed)
(1285) Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats by Xue WL1, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ.(PubMed)
(1286) Dietary fiber in management of diabetes by Vinik AI1, Jenkins DJ.(PubMed)
(1287) Dietary fiber in the management of diabetes by Nuttall FQ1.(PubMed)
(1288) Role of guar and dietary fibre in the management of diabetes mellitus by Cohen M, Leong VW, Salmon E, Martin FI.(PubMed)
(1289) Nutrition, hormones, and breast cancer: is insulin the missing link? by Kaaks R1.(PubMed)
(1290) Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys by McGee WK1, Bishop CV2, Pohl CR3, Chang RJ4, Marshall JC5, Pau FK6, Stouffer RL7, Cameron JL8.(PubMed)
(1291) Role of guar and dietary fibre in the management of diabetes mellitus by Cohen M, Leong VW, Salmon E, Martin FI.(PubMed)
(1292) induced Short-term and long-term effects of excessive consumption of saturated fats and/or sucrose on metabolic variables in Sprague Dawley rats: a pilot study by Pranprawit A1, Wolber FM, Heyes JA, Molan AL, Kruger MC.(PubMed)
(1293) Effects of sugar solutions on hypothalamic appetite regulation by Colley DL1, Castonguay TW2.(PubMed)
(1294) Sugar-sweetened product consumption alters glucose homeostasis compared with dairy product consumption in men and women at risk of type 2 diabetes mellitus by Maki KC1, Nieman KM2, Schild AL2, Kaden VN2, Lawless AL2, Kelley KM2, Rains TM2.(PubMed)
(1295) The wrong white crystals: not salt but sugar as aetiological in hypertension and cardiometabolic disease. DiNicolantonio JJ1, Lucan SC2.(PubMed)
(1296) Effects of diets high in simple sugars on urinary chromium losses by Kozlovsky AS, Moser PB, Reiser S, Anderson RA.(PubMed)
(1297) Artificial sweeteners induce glucose intolerance by altering the gut microbiota by Suez J1, Korem T2, Zeevi D2, Zilberman-Schapira G3, Thaiss CA1, Maza O1, Israeli D4, Zmora N5, Gilad S6, Weinberger A7, Kuperman Y8, Harmelin A8, Kolodkin-Gal I9, Shapiro H1, Halpern Z10, Segal E7, Elinav E1.(PubMed)
(1298) Non-caloric artificial sweeteners and the microbiome: findings and challenges by Suez J1, Korem T, Zilberman-Schapira G, Segal E, Elinav E.(PubMed)