Thursday, June 9, 2016

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: Antioxidants Flavonoids and Coenzyme Q10

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The prevention and management


Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.

Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).

The Common Antioxidants

3. Flavonoids
Flavonoids also known as Vitamin P and citrin are a yellow pigments having a structure similar to that of flavones occurred in varies plants. used in human history for over thousands of years for breakage of capillaries causes of swelling and obstruction of blood flow(553).
Flavonoids process a property as antioxidants for neutralization of many of reactive oxygen species (ROS)(554)(555), including singlet oxygen(556), hydroxyl(557) radicals involved chronic inflammatory diseases(558)(559).
Although nitric oxide is considered a free radical produced by immune system to destroy bacteria induced infection(561), over production can cause increased peroxynitrite which may attack protein, lipid and DNA(560). Flavonoids inhibit NO production of peroxynitrite through various antioxidant enzymes(562).

a. Quercetin
Quercetin is a plant-derived flavonoid found in fruits, vegetables, leaves and grains and studies show that quercetin may have anti-inflammatory(563)(564) and antioxidant(565)(566) properties as a antioxidant, quercetin scavenges free radicals(567), which damage cells (568) and cause mutation of cells with tampering DNA(569)(570).

b. Rutin
Rutin is a citrus flavonoid glycoside found in buckwheat and glycoside of the flavonoid quercetin. It inhibits platelet aggregation(571), decreases the capillary permeability(572), makes blood thinner and improves circulation. As an antioxidant, it also reduces the cytotoxicity of oxidized LDL cholesterol(573) triggered atherogenesis and the risks of other chronic inflammatory diseases(574)(575)(576).

c. Catechin
Catechin is a natural phenol antioxidant and natural anti-bacterial substance. Study showed catechin as good free radical scavenging power inhibits ROS production(577), may be be useful to the development of alimentary strategies to prevent ochratoxin A (OTA) cytotoxicity in human(578). As an antixidant, catchin also process anti inflammatory effects against many chronic inflammatory illness(579)(580)(581)(582).

d. Etc.

4. Coenzyme Q10
Coenzyme Q10 is discovered by Dr. Karl Folfers in 1957, serves as fuel for the cells(583) and acts an antioxidant to prevent the generation of free radicals during this process(584) induced numbers of chronic inflammatory diseases, such as diabetes(585)(586), cardiovascular(587)(588) and Parkinson's disease(589)(590). The antioxidanr also was found effectivetively in the treatment of clomiphene-citrate-resistant PCOS patients through improving ovulation and clinical pregnancy rates when use combination with clomiphene citrate(591).

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References
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