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Chuan Wu (Radix Aconiti Carmichaeli)
Chuan Wu or Fu Zi or Tian Xiong is also known as Common Monkshood Mother Root. The acrid, hot and toxic herb has been used in TCM as sedative, analgesic, anti inflammatory, anti cancer and heart stimulating agent and to treat muscle spasm in cholera; instant sweating, pain and cold in chest and abdomen, chronic diarrhea , etc., as it expels Wind-Damp, disperses Cold, calms pain, restores Yang etc., by enhancing the functions of heart, kidney , spleen channels.
Ingredients
1. Hypaconitine
2. Aconitine
3. Mesaconitine
4. Chuan-wu-base A
5. Chuan-wu base B
6. Carmichaeline
7. Atisines
8. Aminophenols
9. Demethylcoclaurine
10. Higenamine
11. Etc.
Health Benefits
1. De-toxicity
In the investigation of the influence of paeoniflorin (major bioactive component of Paeonia lactiflora Pall.) on the pharmacokinetic behavior of aconitine (major toxic and bioactive component of Aconitum carmichaeli Debx.) and its potential detoxifying effect of paeoniflorin on the acute toxicity of aconitine, found that the acute oral toxicity of aconitine in rats was significantly reduced by paeoniflorin; this might result from the alterations of pharmacokinetic behavior of aconitine in the animals by coadministration of paeoniflorin, according to “Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine” by Fan YF, Xie Y, Liu L, Ho HM, Wong YF, Liu ZQ, Zhou H.(1) .
2. Neuroprotective effect
In the investigation of Chukmesundan (CMSD), composed of the following 8 medicinal herbs including Panex ginseng C.A. MEYER, Atractylodes macrocephala KOID, Poria cocos WOLF, Pinellia ternata BREIT, Brassica alba BOISS, Aconitum carmichaeli DEBX, Cynanchum atratum BGE and Cuscuta chinensis LAM for its effect on hypertension and cerebrovascular disorders used in traditional medicine, found that oral administration of CMSD into mice prevented ischemia-induced learning disability and rescued hippocampal CA1 neurons from lethal ischemic damage. The neuroprotective action of exogenous CMSD was also confirmed by counting synapses in the hippocampal CA1 region. The presence of CMSD in neuron cultures rescued the neurons from nitrogen oxide (NO)-induced death. From these, it was suggested that CMSD may exert its neuroprotective effect by reducing the NO-mediated formation of free radicals or antagonizing their toxicity, according to “Neuroprotective effect of a chuk-me-sun-dan on neurons from ischemic damage and neuronal cell toxicity” by Chung TW, Koo BS, Choi EG, Kim MG, Lee IS, Kim CH.(2).
In the investigation of Chukmesundan (CMSD), composed of the following 8 medicinal herbs including Panex ginseng C.A. MEYER, Atractylodes macrocephala KOID, Poria cocos WOLF, Pinellia ternata BREIT, Brassica alba BOISS, Aconitum carmichaeli DEBX, Cynanchum atratum BGE and Cuscuta chinensis LAM for its effect on hypertension and cerebrovascular disorders used in traditional medicine, found that oral administration of CMSD into mice prevented ischemia-induced learning disability and rescued hippocampal CA1 neurons from lethal ischemic damage. The neuroprotective action of exogenous CMSD was also confirmed by counting synapses in the hippocampal CA1 region. The presence of CMSD in neuron cultures rescued the neurons from nitrogen oxide (NO)-induced death. From these, it was suggested that CMSD may exert its neuroprotective effect by reducing the NO-mediated formation of free radicals or antagonizing their toxicity, according to “Neuroprotective effect of a chuk-me-sun-dan on neurons from ischemic damage and neuronal cell toxicity” by Chung TW, Koo BS, Choi EG, Kim MG, Lee IS, Kim CH.(2).
3. Anti-inflammatory and analgesic effects
In the evaluation of JCICM-6, the extract of an anti-arthritic herbal formula composed of medicinal herbs of Sinomenium acutum, Aconitum carmichaeli DEBX., Curcuma Longa L., Paeonia lactiflora PALL., and Paeonia suffruticosa ANDR., for the effectiveness and mechanism in reducing experimentally-induced inflammation and nociception using nine animal models.
found that JCICM-6 possesses significant anti-inflammatory and analgesic effects, which implies that it would be a potential candidate for further investigation as a new anti-arthritic botanical drug for humans, according to “Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents” by Zhou H, Wong YF, Cai X, Liu ZQ, Jiang ZH, Bian ZX, Xu HX, Liu L.(3).
4. Blood Vessels
In the investigation of The effect of decoctum of Fu-Tze on the blood vessels, found that blood pressure of anaesthetized animal had a rapid, short-durationed drop without significant change of heart function. This depression could be eliminated or blocked by atropine and benadryl.With modified Khayutin’s apparatus it has been shown that decoctum has a significant, direct vasodilatation on the blood vessel of muscle of hind limb, probably owing to the muscaline-like or histamine-like substences it contains, according to “The Effect of Fu-Tze (Aconitum Carmichaeli Debx.) on Blood Vessel of Animals” by Department of pharmacology,Nanking Medical College,Nanking(4).
5. Etc.
Side Effects
1. Raw Chuan Wu is very toxic.
2. Do not use the herb, if you are pregnant
3. Do not use the herb in new born, children or if you are breast feeding with consulting with the related field specialist
4. Only use the herb in cold case related diseases
5. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21930193
(2) http://www.ncbi.nlm.nih.gov/pubmed/16474991
(3) http://www.ncbi.nlm.nih.gov/pubmed/16462027
(4) http://en.cnki.com.cn/Article_en/CJFDTOTAL-YXXB196604003.htm
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