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Wednesday, May 18, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: Turmeric

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment

B. Treatment in herbal and traditional Chinese medicine
B.8. Herbal and Traditional Chinese medicine
Many herbal medicine have been found effectively for reduction of symptoms and treatment for patient with osteoarthritis(340), including
B.8.1. Individual herb
11. Turmeric
Turmeric, a cooking spice used in many culture in South East Asian, especially in India, also has been used as herbal medicine over thousands of year(373). Curcumin (CM), a yellow hydrophobic polyphenol derived from the herb turmeric, reduced inappropriate inflammatory responses through expression in inhibiting cell proliferation and metastasis and downregulating various factors, including the inflammatory cytokines and pathway(372) in animal model.
In acute and chronic inflammation, including Rheumatoid Arthritis, curcumin showed to inhibit inflammatory cell proliferation, invasion, and angiogenesis through multiple molecular targets and mechanisms of action, such as down-regulation of inflammatory transcription factors, cytokines,......related to expression of RA(374).
Dr. Park C and the research team at the Dongeui University College of Oriental Medicine suggested that the effectiveness of curcumin for treatment of RA is due to its inhibited of prostaglandin E(2) through numeral pathways such as hyperplasia of the synovial fibroblasts(375).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

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References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(340) Expert consensus on the treatment of rheumatoid arthritis with Chinese patent medicines by Zhao J1, Zha Q, Jiang M, Cao H, Lu A(PubMed)

(372) The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats by Zheng Z1, Sun Y2, Liu Z1, Zhang M1, Li C1, Cai H3.(PubMed)
(373) Clinical utility of curcumin extract by Asher GN1, Spelman K.(PubMed)
(374) Curcumin in inflammatory diseases. by Shehzad A1, Rehman G, Lee YS.(PubMed)
(375) Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients withrheumatoid arthritis by Park C1, Moon DO, Choi IW, Choi BT, Nam TJ, Rhu CH, Kwon TK, Lee WH, Kim GY, Choi YH.(PubMed)

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