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Da Ji is also known as Japanese thistle or thistle roots. The sweet and cold herb has been used in TCM to treat nose bleeding, blood in urine, bleeding not during menses, vaginal discharge, pain in intestine, abscess in intestine, etc., as it cools Blood, stops bleeding, eliminates Blood stasis, resolves abscesses, etc., by enhancing the functions of liver, lung, spleen, kidney channels.
4. 5,7’-dihydroxy-6,4′- dimethoxyflavone
7. 32 cosanol
1. Antidiabetic effect
In the evaluation of the isolation of two flavones from Cirsium japonicum DC, pectolinarin and 5,7-dihydroxy-6,4′-dimethoxy flavone (DDMF), and their antidiabetic effect in diabetic rats,
indicated that indicated that the flavones improved adiponectin expression, accompanied by restoring of the dysregulated activities of the glucose metabolism-related enzymes, ultimately resulting in well improved glucose and lipid homeostasis. Thus, an antidiabetic effect of Cirsium japonicum DC was revealed in diabetic rats, according to “Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats” by Liao Z, Chen X, Wu M.(1).
2. Anticancer activity
In the investigation of Cirsium japonicum DC flavone compounds, pectolinarin and 5,7-dihydroxy-6,4′-dimethoxyflavone, determined by HPLC as follows: pectolinarin 1.87%, 1.65%, 1.27%; 5,7 dihydroxy-6,4′-dimethoxyflavone: 0.515%, 0.42%, 0.221%, found that shows that these two flavones greatly inhibit cancer cell growth. The rate of inhibiting S180 mice was 55.77% at 50 mg kg( – 1), and the rate of life lengthening was 99.13% at 50 mg kg( – 1) in H22 mice, according to “Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC” by Liu S, Zhang J, Li D, Liu W, Luo X, Zhang R, Li L, Zhao J.(2).
3. Tumor inhibition and improved immunity
In the study of the effects of flavone from Cirsium japonicum DC (FLCJ) on tumor activity and on the regulation of the immune response in mice with S180 and H22 tumors. Pectolinarin and 5, 7-dihydroxy-6, 4′-dimethoxyflavone are two major components of FLCJ, found that the tumor inhibition of FLCJ had close relation with its regulation of the immune response Furthermore, this tumor inhibition by FLCJ may activate the innate immune system, which would be expected as a potential anti-tumor drug, according to “Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC” by Liu S, Luo X, Li D, Zhang J, Qiu D, Liu W, She L, Yang Z.(3).
In the observation of the effect of neuritogenesis of Polyacetylenic alcohols and their linoleates isolated from Panax ginseng C. A. MEYER and Cirsium japonicum DC., found that the promotion of neuritogenesis in cultured paraneurons by the addition of panaxynol is related its ability to improve memory deficits in animals, according to “Effect of polyacetylenes on the neurite outgrowth of neuronal culture cells and scopolamine-induced memory impairment in mice” by Yamazaki M, Hirakura K, Miyaichi Y, Imakura K, Kita M, Chiba K, Mohri T.(4).
1. Do not use the the herb in case of spleen deficiency and without blodd stasis.
2. Do not use the herb in newborn, children ot if you are pregnant or breast feeding with out first consulting with the related field specialist.
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