Chaste tree berry, The Whole Herb Medicine in Ameliorated Symptoms and Treatment of Premenstrual Syndrome

Chaste tree berry, the queen of all herbs may have potency in reduced symptoms and treatment of the premenstrual syndrome.

According to Dr. Döll M, the extract of chaste tree berry decreased levels of prolactin serum during the first 3 weeks of the cycle of the premenstrual period, inducing stress involved expression of symptoms of PMS.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, considered as Queen herb in treating menstrual problems and discomforts and used in herbal medicine for thousands of year as an aphrodisiac agent.

Premenstrual syndrome is a faulty function of the ovaries related to the women's menstrual cycle, affecting women's physical and emotional state, and sometimes interfering with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.


In a prospective, double-blind, placebo-controlled, parallel-group, multi-center clinical trial in compared VAC BNO 1095 extract and placebo for up to three cycles, conducted by the Peking Union Medical College Hospital, group treated with extract of vitex agnus castus showed a significant reduced symptoms of PMS with mean total PMSD score decreased from 29.23 at baseline (0 cycle) to 6.41 at the termination (3rd cycle) with no serious of side effects.


Furthermore, the extract of vitex agnus castus (VAC, BNO 1095) oral administrated in 67 patients enrolled and randomly assigned to receive one tablet of VAC or placebo once a day, exhibited the decreased premenstrual syndrome symptoms at the 3rd cycle, including symptoms of negative affect, water retention, food cravings, and pain, in the treatment group, compared to placebo group, especially in symptoms of water retention.


The moderate-to-severe premenstrual syndrome in Chinese women study also showed a significantly greater improvement of symptoms with intake of vitex agnus castus (VAC, BNO 1095)group than placebo, including the symptom of insomnia.

Taking together, Chaste tree berry may be a safe herbal medicine for the treatment of PMS, through decreased levels of prolactin, negative factors and ameliorated symptoms of the syndrome in many aspects.

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Sources
(1) [The premenstrual syndrome: effectiveness of Vitex agnus castus].[Article in German]by Döll M1.(PubMed)
(2) Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China by He Z1, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, Yao Y, Lu J, Lin S.(PubMed)
(3) Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus(BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Wang X.(PubMed)
(4) Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Zhang Y, Chen F, Wang X.(PubMed)