Cinnamon, The Best Whole Herb medicine in stimulated Immunomodulatory effect against Inflammatory Diseases

Intake of cinnamon in patients is found to enhance the immunomodulatory effect. According to the study by the Kyung Hee University, water extract of cinnamon bark (CWE) involved proteins in intracellular signaling molecules in activated T cells without exhibiting allergic, stress and overreaction of antibody effects.


The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections.

Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

The impact of CBEO on 17 protein biomarkers play critical roles in inflammation and tissue remodeling.
In a Human Skin Disease Model. researchers found that cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) significantly inhibited an immunomodulatory protein molecule in the expression of inflammation'


Dr. Pahan K, said, " Sodium benzoate (NaB), a metabolite of cinnamon, improve immunomodulatory activities in regulated many immune signaling pathways responsible for inflammation, glial cell activation, switching of T-helper cells, modulation of regulatory T cells, cell-to-cell contact, and migration.....".

Furthermore, the approved metabolite of cinnamon also found to modify T cells at multiple steps and inhibit the adoptive transfer of experimental allergic encephalomyelitis.


In patients with Orofacial granulomatosis (OFG), a chronic inflammatory disorder, cinnamon- and benzoate-free diet (CB-free diet) improves symptoms of swelling, particularly with regard to oral inflammation, probably through immunomodulatory effect.


Taking all together, there is no doubt that intake of whole herbal cinnamon protects patients against inflammatory disease through activation of immunomodulatory activities, such as arthritis, asthma, colitis,...etc.


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Sources
(1) Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation by Lee BJ1, Kim YJ, Cho DH, Sohn NW, Kang H.(PubMed)
(2) Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model by Han X1, Parker TL1.(PubMed)
(3) Immunomodulation of experimental allergic encephalomyelitis by cinnamon metabolite sodium benzoate by Pahan K1.(PubMed)
(4) Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis by Brahmachari S1, Pahan K.(PubMed)
(5) Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet by White A1, Nunes C, Escudier M, Lomer MC, Barnard K, Shirlaw P, Challacombe SJ, Sanderson JD.(PubMed)