Herbal Anise In Reduced Risk, Progression and Treatment of Colon Cancer

Anise may have a potential and substantial effect in reduced risk and progression and treatment of colon cancer, some scientists suggested.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the study of a green synthesis route to produce AgNPs by using an aqueous extract of Pimpinella anisum seeds (3 mM) on human neonatal skin stromal cells (hSSCs) and colon cancer cells (HT115) researchers found that under influence of Anise extract, AgNPs exhibited a strong cytotoxicity effect against hSSC cells and HT115 cells through inhibited the cell proliferation and induced apoptosis, in a dose-dependent manner, according to proliferation tests and cell viability assays.

Further differentiation also suggested that green-synthesized AgNPs exerted a significant effect against five infectious bacteria: Staphylococcus pyogenes (29213), Acinetobacter baumannii (4436), Klebsiella pneumoniae (G455), Salmonella typhi, and Pseudomonas aeruginosa which have been associated to increase risk of colon cancer.



After taking into account of other confounders, Dr. Alsalhi MS, the lead author suggested that
P. anisum-synthesized AgNPs as novel and cheap agents for eco-friendly nanosynthetical routes in treatment of colon cancer.



Moreover, the examine 3 commercially grown native herbs unique to Australia, Tasmannia pepper leaf (Tasmannia lanceolata R. Br., Winteracea; TPL), anise myrtle (Syzygium anisatum Vickery, Craven & Biffen, Myrtaceae; AM) and lemon myrtle (Backhousia citriodora F. Muell, Myrtaceae; LM) as well as a reference sample bay leaf (Laurus nobilis L., Lauraceae; BL), cytoprotective properties in colon adenocarcinoma (HT-29) cells, indicated that Anise demonstrated a potential effect in inhibited colon cancer cell line HT-29 with IC(50) through
increased antioxidant activity in reduced expression reactive oxygen species in initiation of cancer cell proliferation.

Additionally, Application of Anise promoted colon cancer cells death by activating caspase-3 enzyme in enhanced the killer T cells activity to initiate cancer cells apoptosis by killer T cells.

According to the Cytokinesis-block micronucleus cytome assay, application of Anise extract inhibited colon adenocarcinoma (HT-29) cells at concentration of 0.5 and 1.0mg/ml. without causing harm to the neighbor healthy cells

The above analysis were supported by the study in evaluated the effect of the volatile preparations of essential oils of the Greek plants Ocimum basilicum (sweet basil), Mentha spicata (spearmint), Pimpinella anisum (anise) and Fortunella margarita (kumquat) on model of human colon carcinoma.

Application of the herbal preparation expressed a significant activity in precipitated cytotoxicity effect in some infectious microorganisms associated to facilitation of the early stage of colon cancer.

According to the DPPH and ABTS assay, application of all herbal essential oils also increased expression of antioxidant in decreased free radical expression in elevated cancer cell in cycle division.


Dr. Fitsiou E, the lead author said, "All essential oil preparations exhibited a variable degree of antiproliferative activity, depending on the cancer model used, with the most potent one being sweet basil against an in vitro model of human colon carcinoma".

The information findings suggested that Anise may be considered as a functional herb for reduced risk, progression and treatment of colon cancer. However, intake of Anise extract should be taken with care as some supplement have been found to induced acute liver toxicity.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells by Alsalhi MS1, Devanesan S1, Alfuraydi AA2, Vishnubalaji R3, Munusamy MA2, Murugan K4, Nicoletti M5, Benelli G6.(PubMed)
(2) Cytoprotective and pro-apoptotic activities of native Australian herbs polyphenolic-rich extracts by Sakulnarmrat K1, Fenech M, Thomas P, Konczak I.(PubMed)
(3) Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita by Fitsiou E1, Mitropoulou G2, Spyridopoulou K3, Tiptiri-Kourpeti A4, Vamvakias M5, Bardouki H6, Panayiotidis MΙ7, Galanis A8, Kourkoutas Y9, Chlichlia K10, Pappa A11.(PubMed)