Myelotoxicity is a medical condition that causes the decrease of the production of cells responsible for immunity (leukocytes), carrying oxygen (erythrocytes), and/or for normal blood clotting (thrombocytes) due to bone marrow suppression.
Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.
Myeloperoxidase (MPO) processes a critical role that protects our body against the invasion of microorganisms.
In cellular levels, myeloperoxidase (MPO) plays a critical role as a local mediator of tissue damage by stimulating the production of proinflammatory cytokines to protect the cell against foreign pathogens in the induction of acute phase of infection.
In other words, MPO deficiency induces the exaggerates of the inflammatory response that affects neutrophil functions including cytokine production in the acute phase of infection that can lead to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic preposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degrees of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in the primary form".
And, " Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of neutropenia, researchers examined the effects of Tussilago farfara L. polysaccharides on the immune response of the lung cancer animal model.
The study included selected C57Bl/6 mice with Lewis lung carcinoma treated by conventional cisplatin/paclitaxel polychemotherapy before administrating additional Tussilago farfara L. polysaccharides.
According to the tested analysis, Tussilago farfara L. polysaccharides not only reduced the side effects of cisplatin/paclitaxel polychemotherapy induced myelotoxicity associated with moderated neutropenia but also enhanced the efficacy of the chemo drugs activity.
Moreover, the stimulating effect of polysaccharides on the granulopoiesis lineage cells involved in myelopoiesis that differentiate into unipotent neutrophil progenitors in the lung tumor cells compared to those of CSF Neupogen.that increase production of white blood cells in the body.
In other words, polysaccharides exhibited immune-modulating activity against myelotoxicity induced by chemo drug side effects.
Taken altogether, coltsfoot may be considered a remedy for the improvement of myelopoiesis, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L by Safonova EA1, Lopatina KA2, Razina TG2, Zueva EP2, Fedorova EP2, Gur'ev AM3, Belousov MV. (PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa, and Ishwarlal Jialal. (NCBI)
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