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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Bing Pian (Borneolum)
Bing Pian or Ai Pian is also known as Borneol, is is a bicyclic organic compound and a terpene, native to Southeast Asia. The acrid, warm, toxic herb has been used in TCM to stimulates the production of gastric juices, improves circulation, treats bronchitis, coughs and colds and relieve pain as it opens the orifices, restores consciousness, clears heat and relieve pain by promoting the functions of heart, spleen, liver, lung channels.
4. B- borneol
8. Oleanolic acid
The chemical compound Isoborneol is an antiseptics which uses to reduce infection, sepsis, or putrefaction. if applied to living tissue/skin by destroying them, preventing or inhibiting the growth of bacteria.
Oleanolic acid, a naturally triterpenoid, widely used in food and medicinal plants, it helps to reduce the risk of inflammation due to its property as an inhibitor of cellular inflammatory processes and to protect cells against oxidative and electrophile stress due to its property of potent inducers of the phase 2 response, by elevating of NADH-quinone oxidoreductase and heme oxygenase.
Humulene, a essential oils in Bing pain, is a naturally-occurring monocyclic sesquiterpene. It may be used as an antiseptic, antibacterial, or anti-inflammatory and as a calming agent by aromatherapists.
Camphor is easily absorbed through the skin and produces a cooling feeling and acts as local anesthetic and antimicrobial agent.
5. Neuroprotective effects
Sodium ferulate, when orally co-administered with borneol have shown the activity in against injury induced in the brain by ischaemia/reperfusion in mice, according to the study of “The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL/6J mice” by Chen XH, Lin ZZ, Liu AM, Ye JT, Luo Y, Luo YY, Mao XX, Liu PQ, Pi RB., posted in PubMed(1).
Bing Pain also have shown the activity in against the destabilization of β-amyloid (Aβ) peptide aggregates that causes Alzheimer’s disease (AD) and protecting SH-SY5Y cells and VSC 4.1 cells against H(2)O(2)-induced toxicity, according to the study of “Salvianic borneol ester reduces β-amyloid oligomers and prevents cytotoxicity” by Han M, Liu Y, Zhang B, Qiao J, Lu W, Zhu Y, Wang Y, Zhao C., posted in PubMed(2).
7. Salvianolic acid and Cardiovascular disease
Bing Pain enhances the digestive absorption of salvianolic acid (according to the study of “[Intestinal absorption properties of three components in salvianolic acid extract and the effect of borneol on their absorption in rats].[Article in Chinese]“ by Lai XJ, Liu HQ, Li JS, Di LQ, Cai BC., posted in PubMed(3)) an ingredient of Red Sage which have shown the properties in treating angina pectoris, hyperlipidemia, and acute ischemic stroke, according to the article of “Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection” by Jennifer Hui-Chun Ho and Chuang-Ye Hong, posted in PubMed Central(4).
Do not use during pregnancy, due to its toxic effects
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